Reviewed by Alina Shrourou, B.Sc. (Editor)Nov 1 2018Integral Molecular, the industry leader in membrane protein technologies, was awarded a Small Business Innovation Research (SBIR) grant from the NIH to initiate a target discovery program for Alzheimer’s disease. Under the grant, Integral Molecular will use its highly successful Membrane Proteome Array (MPA) platform to discover novel neuroimmune targets for treating Alzheimer’s and other neurodegenerative diseases.Neurodegenerative diseases are a leading cause of death and disability for 6.5 million older Americans. A major roadblock in the development of new treatments has been the lack of druggable targets. Recent research suggests that dysregulation of the immune system can cause or exacerbate many neurodegenerative diseases. The identification of new proteins that can regulate the neuroimmune system could enable the discovery of an entirely new generation of therapeutics with the potential to treat, delay, or even prevent Alzheimer’s disease.Related StoriesNew research links “broken heart syndrome” to cancerStudy finds sex-specific differences in risk and progression of Alzheimer’s diseaseMother calls for protein shake regulation after daughter dies”The lack of effective targets in Alzheimer’s disease has held back the discovery of new drugs to treat it,” says Benjamin Doranz, CEO of Integral Molecular. “We have already identified new targets in the immuno-oncology and infectious disease fields using our MPA platform, so we are excited to expand our work to include neurodegenerative diseases.”Integral Molecular’s MPA technology is composed of 5,300 human membrane proteins expressed in their functional form on the surface of live human cells, allowing signaling and binding assays to detect functional interactions. Integral Molecular has already used the MPA to identify novel targets and protein interactions in various therapeutic areas, as well as to obtain off-target binding profiles to de-risk drug development. Source:https://www.integralmolecular.com/
This article was reprinted from khn.org with permission from the Henry J. Kaiser Family Foundation. Kaiser Health News, an editorially independent news service, is a program of the Kaiser Family Foundation, a nonpartisan health care policy research organization unaffiliated with Kaiser Permanente. Reviewed by James Ives, M.Psych. (Editor)Jan 18 2019Joseph Daskalakis’ son was born New Year’s Eve, a little over a week into the current government shutdown, and about 10 weeks before he was expected.Little Oliver ended up in a specialized neonatal intensive care unit, the only one that could care for him near their home in Lakeville, Minn.But air traffic controller Daskalakis, 33, has an additional worry: The hospital where the newborn is being treated is not part of his current insurer’s network and the partial government shutdown prevents him from filing the paperwork necessary to switch insurers, as he would otherwise be allowed to do. He could be on the hook for a hefty bill — while not receiving pay. Daskalakis is just one example of federal employees for whom being unable to make changes to their health plans really matters.Although the estimated 800,000 government workers affected by the shutdown won’t lose their health insurance, an unknown number are in limbo, like Daskalakis, unable to change insurers because of unforeseen circumstances; add family members such as spouses, newborns or adopted children to an existing health plan; or deal with other issues that might arise.”With 800,000 employees out there, I imagine that this is not a one-off event,” said Dan Blair, who served as both acting director and deputy director of the federal Office of Personnel Management (OPM) during the early 2000s and is now senior counselor at the Bipartisan Policy Center. “The longer this goes on, the more we will see these types of occurrences.”While Oliver is getting stronger every day — he’s now out of the ICU, according to Daskalakis’ local air traffic union representative — it’s unclear how the situation will affect his family’s finances.That’s because out-of-network charges are generally far higher than being in-network, and NICU care is enormously expensive no matter what. Those bills could add up, especially as his current insurance has an out-of-pocket maximum of $12,000 annually. Because Oliver was born before the new year, the family could face that amount for 2018 — and 2019.Daskalakis isn’t getting paid, either.”I don’t know when I’ll be able to change my insurance, or when I’ll get paid again,” Daskalakis wrote Sen. Tina Smith (D-Minn.), who shared his letter on Facebook and before the Senate last week.Other families are also worried about paperwork delays, and the financial and medical effects a prolonged shutdown could cause.Dania Palanker, a health policy researcher at Georgetown’s Center on Health Insurance Reforms, studies what happens when families face insurance difficulties. Now she’s also living it.After arranging to reduce her work hours because of health problems, Palanker knew her family would not qualify for coverage through her university job. No problem, she thought, as she began the process in December to enroll her family into coverage offered by her husband’s job with the federal government.Related StoriesBordeaux University Hospital uses 3D printing to improve kidney tumor removal surgeryHome-based support network helps stroke patients adjust after hospital dischargeStudy analyzes high capacity of A. baumannii to persist on various surfaces”We could not get the paperwork in time to apply for special enrollment through the government and get it processed before the shutdown,” Palanker said.Georgetown allowed her to boost her work hours this month to keep the family insured through January, but Georgetown’s share of her coverage will end in February.Her treatments are expensive, so she is likely to hit or exceed her annual $2,000 deductible in January — then start over with another annual deductible once the family secures new coverage.”I’m postponing treatment in hopes that it is just a month and I’m back on the federal plan in February, but I can’t postpone indefinitely, as my condition will get worse,” said Palanker, who has an autoimmune disease that causes nerve damage.Overseeing federal health benefits programs is within the purview of the OPM, whose data hub is operational, according to a spokeswoman. But getting information to that data hub to make the kind of changes Daskalakis, Palanker and others need depends on the individual agencies that employ government workers.The OPM has told government agencies “that they should have HR staff available during the lapse, specifically to process” such requests, which are called “qualifying life events,” the spokeswoman said.In a written statement Wednesday, Smith said: “Oliver’s story is a powerful reminder that hundreds of thousands of real families have had their financial and personal lives turned upside down by this unnecessary shutdown.” She called on the president to come back to the negotiating table.For Daskalakis, there is some good news.Tony Walsh, his union rep, said the OPM website and Daskalakis’ insurer both indicated that the air traffic controller’s request to change carriers so the hospital will be in-network will be retroactive to Oliver’s birthday, and the out-of-network charges may not play a role.Just to be safe, “Joe is currently working on an insurance appeal based on no in-network care [being available],” Walsh said in an emailed statement. The family has already received an initial $6,000 bill from the hospital, Walsh noted, saying the charges do not include costs associated with Oliver’s birth or his stay in the intensive care unit.Walsh said the shutdown is affecting a broad swath of employees in ways many lawmakers had never anticipated.The workers “are essential to the system, and it’s unfair they are being treated this way,” he said.
FILE PHOTO: Britain’s Secretary of State for Exiting the European Union Stephen Barclay arrives at Downing Street in London, Britain June 11, 2019. REUTERS/Peter NichollsLONDON (Reuters) – The chances of Britain leaving the European Union without a deal at the end of October are underpriced, Britain’s Brexit minister Stephen Barclay said on Wednesday. Asked about the likelihood of a no-deal Brexit, Barclay pointed to the fact that parliament is only due to sit for a relatively short period of time in September and October and that legislation required to pass a deal would be significant. “I think a no deal is underpriced. It is still this government’s intention and both leadership candidates’ intention to seek a deal and I think it is the will of many members of parliament for there to be a deal,” he told a committee of lawmakers. “But the question then will be is there a deal that is palatable to parliament and if not will parliament vote to revoke or will we leave with no deal?” Reporting by Kylie MacLellan, editing by Elizabeth PiperOur Standards:The Thomson Reuters Trust Principles.
SHARE SHARE EMAIL Saying the general elections in a Democracy were akin to a sacred ritual, President Ram Nath Kovind on Friday urged all citizens to be part of this ritual by participating in the upcoming Lok Sabha polls.“Each vote will encourage another voter, and each vote will strengthen our Democracy,” the President said at a function to celebrate the 9 National Voters Day. The President said every vote counts equally in the formation of the government, adding that large organisations functions under the Election Commission (EC) to ensure that every voter is able to exercise his or her voting right.“The complexity of the task — beginning with the preparation of electoral rolls and concluding with the declaration of election results — is difficult to comprehend for an ordinary person. Yet, through all this, the credibility of our electoral system has continuously strengthened. Our voters have a firm belief in the integrity, diligence, fairness and transparency of the EC and the electoral process,” the President said.The President was also of the opinion that the country’s size and the logistics of holding elections makes it critical to embrace modern technology.Ravi Shankar Prasad, Minister for Law said there was a need to not only trust but also respect the sanctity of the EC.Without naming any political party, the Minister said the electronic voting machines (EVMs) had also decided the victory and defeat of the party that he represented.Inclusive approachSunil Arora, Chief Election Commissioner outlined the various initiatives which the Commission has taken to ensure that all categories of voters are included in the electoral process.“The Commission has taken initiatives for enhancing women’s participation and the turnout of women voters in recent elections has been encouraging,” Arora said adding that the Commission is committed to making the electoral process accessible to all persons with disabilities.Election Commissioner Ashok Lavasa said the gender gap has come down from 16.7 per cent in 1962 elections to 1.5 per cent in 2014 with women’s participation in the electoral process increasing from 46.6 per cent to 65.06 per cent. Published on SHARE January 25, 2019 democracy COMMENT Republic Day Urges citizens to take part in the upcoming Lok Sabha polls India Ram Nath Kovind, President of India COMMENTS
Anshula Kant. File | Photo Credit: MAIL Related TopicsBusinessInternational Printable version | Jul 13, 2019 8:34:29 PM | https://www.thehindu.com/news/international/indias-anshula-kant-is-world-bank-md-and-cfo/article28415426.ece Washington DC, more-in We may remove hyperlinks within comments. Ms. Kant will be the first woman CFO of the Bank Comments Washington DC, Previous StoryU.S. regulators approve $5 billion Facebook settlement over privacy issues: source PRINT Recommended for you SUBSCRIBE TO OUR DAILY NEWSLETTER The article had erroneously stated that Anshula Kant was the first woman MD of The World Bank Share Article Updated: Please write complete sentences. Do not type comments in all capital letters, or in all lower case letters, or using abbreviated text. (example: u cannot substitute for you, d is not ‘the’, n is not ‘and’). July 13, 2019 01:33 IST Please use a genuine email ID and provide your name, to avoid rejection. Sriram Lakshman The World Bank Group on Friday announced that Anshula Kant, an Indian national, has been appointed its next MD and CFO. Ms. Kant will be the first woman CFO of the Bank.“Anshula brings more than 35 years of expertise in finance, banking, and innovative use of technology through her work as CFO of the State Bank of India,” World Bank Group president David Malpass said via a statement.“She’s excelled at a diverse array of leadership challenges including risk, treasury, funding, regulatory compliance and operations. I look forward to welcoming her to our management team as we work to increase our effectiveness in supporting good development outcomes.” Play VideoPlayUnmuteCurrent Time 0:00/Duration Time 0:00Loaded: 0%Progress: 0%Stream TypeLIVERemaining Time -0:00 Playback Rate1ChaptersChaptersdescriptions off, selectedDescriptionssubtitles off, selectedSubtitlescaptions settings, opens captions settings dialogcaptions off, selectedCaptionsAudio TrackFullscreenThis is a modal window.The media could not be loaded, either because the server or network failed or because the format is not supported.Caption Settings DialogBeginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsDefaultsDoneMs. Kant will be responsible for financial and risk management and report to Mr. Malpass. Her duties will include risk management and financial reporting and she will work with the Bank’s CEO to mobilise financial resources.Ms. Kant has holds an Honours degree in Economics from Lady Shri Ram College and a post-graduate degree in Economics from the Delhi School of Economics. Sriram Lakshman Comments will be moderated by The Hindu editorial team. Comments that are abusive, personal, incendiary or irrelevant cannot be published. Comments July 13, 2019 01:33 IST SubmitPlease enter a valid email address. © THG PUBLISHING PVT LTD. Close XNorth Korea’s new Constitution calls Kim Jong-un head of state instead of ‘supreme leader’China to impose sanctions on U.S. firms in Taiwan arms sale 25 injured as quake rocks southern PhilippinesRussia’s top missile system has many buyers 26 dead as Somali forces end extremist siege of Kismayo hotelPrasar Bharati chief accuses The Caravan editor of ‘blatant’ anti-India presentation at global meet U.S. will consider ‘301 probe’ on India, says trade official Trump says nationwide immigration arrests to begin on Sunday17 killed as heavy rains lash Nepal Pakistan Foreign Minister Qureshi heckled in London over media freedom North Korea’s new Constitution calls Kim Jong-un head of state instead of ‘supreme leader’China to impose sanctions on U.S. firms in Taiwan arms sale 25 injured as quake rocks southern PhilippinesRussia’s top missile system has many buyers 26 dead as Somali forces end extremist siege of Kismayo hotelPrasar Bharati chief accuses The Caravan editor of ‘blatant’ anti-India presentation at global meet U.S. will consider ‘301 probe’ on India, says trade official Trump says nationwide immigration arrests to begin on Sunday17 killed as heavy rains lash Nepal Pakistan Foreign Minister Qureshi heckled in London over media freedom North Korea’s new Constitution calls Kim Jong-un head of state instead of ‘supreme leader’China to impose sanctions on U.S. firms in Taiwan arms sale 25 injured as quake rocks southern PhilippinesRussia’s top missile system has many buyers 1 / 10 2 July 12, 2019 22:41 IST Next Story Child suicide bomber kills 5 at wedding in Afghanistan India’s Anshula Kant is World Bank MD and CFO International AD Quality Auto 360p 720p 1080p July 12, 2019 22:41 IST Updated: FigLeaf AppComplete Online Anonymity Is One Click AwayFigLeaf App|SponsoredSponsoredUndoProgressive$699 average annual savings for drivers who switch and save.Progressive|SponsoredSponsoredUndoDermal MedixIf You Have Turkey Neck Or Double Chin, This Can Fix It FastDermal Medix|SponsoredSponsoredUndoKelley Blue Book10 Electric Cars That Last the LongestKelley Blue Book|SponsoredSponsoredUndoThrone: Free Online GamesPlay this for 1 minute and see why everyone is addicted!Throne: Free Online Games|SponsoredSponsoredUndoFisher InvestmentsAre You Ready for Retirement? 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