Doctoral thesis focuses on the role of oxidative stress in Wolfram syndrome

first_img Source:Estonian Research Council Oxidative stress is the cause for concern primarily for those whose organism has more reactive species or whose antioxidant defense system is weaker. Deficient defense system may also result from the scarcity of certain vitamins.”Rando Porosk, doctoral candidate of the Institute of Biomedicine and Translational Medicine at the University of Tartu Related StoriesHealthy lifestyle lowers dementia risk despite genetic predispositionStudy reveals long-term benefits of stress urinary incontinence surgeryNew study identifies eight genetic variants associated with anorexia nervosaIn his doctoral thesis titled “The Role of Oxidative Stress in Wolfram Syndrome 1 and Hypothermia”, Porosk studied the role of oxidative stress in the case of mild hypothermia or reduced body temperature as well as rare Wolfram syndrome. The latter is caused by a wolframin gene defect which also causes diabetes insipidus, diabetes mellitus, optical nerve atrophy and neurodegenerative disorders. A person suffering from this syndrome has diabetes as well as he/she will be blind and deaf.According to the doctoral candidate, there is knowledge of Wolfram syndrome in the case of wolframin deficiency, as intracellular endoplasmic stress, as well as oxidative stress occurs. “We described the level of oxidative stress more profoundly than ever before in the model of mice suffering from Wolfram syndrome constructed by us and showed how the antioxidant UPF peptides designed by us decrease oxidative stress in various tissues.”In Porosk’s doctoral thesis, the animal model has been described better when compared with earlier ones. This animal model can now be used in further research for describing Wolfram syndrome. “Profound description of metabolism provides information for further studies on a protein with hitherto unknown biofunction which is also wolframin that causes Wolfram syndrome. This way, its biofunction can be described even more profoundly.”The mild hypothermia is used quite a lot in clinical practice for avoiding tissue damage. Right now, it is not exactly known what the protective hypothermia mechanism is about. “We showed in the research that mild hypothermia causes a stress response in various cell lines,” said Porosk in conclusion.center_img Reviewed by Kate Anderton, B.Sc. (Editor)May 29 2019In the Faculty of Medicine at the University of Tartu, the first animal testings were conducted using antioxidant peptides designed and synthesized by scientists in Tartu, which may reduce oxidative stress. Oxidative stress also develops with a rare incurable genetic disease called Wolfram syndrome and it is studied profoundly by scientists all over the world.Doctoral candidate of the Institute of Biomedicine and Translational Medicine at the University of Tartu, Rando Porosk, explained that oxidative stress is a condition where the reactive species, such as free radicals, dominate over the antioxidant defense system, and this may cause tissue damage as a result, for example.last_img read more

Enhancing the competitiveness of the railway sector

first_img Citation: Enhancing the competitiveness of the railway sector (2018, June 28) retrieved 18 July 2019 from https://phys.org/news/2018-06-competitiveness-railway-sector.html Enhancing the competitiveness and attractiveness of the railway sector – the core ambition of the Shift2Rail joint undertaking – requires other projects to clear the way. The ROLL2RAIL project played this role by focusing on novel rolling stock technologies and methodologies. Future trains should be more energy-efficient, lighter, more reliable, have more capacity, cost less over their life cycle, be connected and be more comfortable and attractive. Only then will the railway sector be able to raise its market share. Of course, getting there won’t be easy: there are many obstacles to such radical innovation, and technologies with the potential to rise to this challenge are only in their infancy. This is the context that saw the launch of ROLL2RAIL (New Dependable Rolling Stock for a More Sustainable, Intelligent and Comfortable Rail Transport in Europe), an EU-funded project aiming to develop key technologies and remove blocking points for radical innovation in the field of rolling stock. Being part of a wider long-term strategy to shape the rolling stock of the future and ensure suitable results for integration in Shift2Rail, the project addressed several sub-systems including traction, TCMS, carbody, running gear, brakes, interiors, noise and energy.”Traction systems have reached their maximum possible efficiency with current power electronics technology (silicon). Our goal was to reap all the benefits of incipient silicon carbide semiconductor technology to create smaller, lighter, more efficient and more reliable railway traction systems, while at the same time addressing low-floor wheel-motor assemblies for high-speed trains,” Mr Andrea Demadonna, coordinator of the project on behalf of UNIFE (The European Rail Industry Association), explains. “We also studied key aspects of performance such as noise emission or reliability/availability, along with possible technical standardisation that will lead to cost reductions.”In 30 months, ROLL2RAIL achieved a substantial reduction in the weight and volume of traction converters and motors, and produced calculations for motor cooling noise and specifications for a semi-conductor based on environmental conditions.Besides traction, the project led to numerous breakthroughs. The first is a Train Control & Management System (TCMS) that uses wireless technologies for train control and monitoring functions, thereby removing the need for onboard communication cables and simplifying the train coupling procedure. The second is a study on adhesive joints as well as on the reduction in weight linked to composite materials; and the third is a market push for running gear technologies and maintenance – in the form of a Europe-wide cost modelling methodology that can quantify the global impact of running gear performance on the economics of the whole railway system.That’s only the tip of the iceberg, as the project also resulted in the following: a set of reduced and harmonised requirements for a braking system to be used in future authorisation processes; a study of publicly available passenger surveys on train comfort and a weighted flexible scoring metric including 24 comfort features; three new noise separation methods (advanced transfer path analysis, beamforming and wave signature extraction) which were tested in real conditions; and an energy norms and standards application guide for KPI generation as well as a calculation methodology. Finally, the consortium developed a KPI tool to assess the impact/improvements of new developments against a baseline.”ROLL2RAIL results have been designed for use by Shift2Rail as the ultimate end-user. Their benefits will impact not only Innovation Programme 1 (Rolling Stock for passengers) but also advanced traffic management and control systems, infrastructure, freight and cross-cutting activities (CCA) such as noise and energy,” Demadonna says. “Shift2Rail will now continue the work we started, in a process that is only natural when considering that more than half of the ROLL2RAIL partners are also members of Shift2Rail.” Explore further Provided by CORDIScenter_img Credit: Denis Belitsky, Shutterstock Designing the future of rail travel This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Brexit minister Barclay says chances of a no deal EU exit are

first_imgFILE PHOTO: Britain’s Secretary of State for Exiting the European Union Stephen Barclay arrives at Downing Street in London, Britain June 11, 2019. REUTERS/Peter NichollsLONDON (Reuters) – The chances of Britain leaving the European Union without a deal at the end of October are underpriced, Britain’s Brexit minister Stephen Barclay said on Wednesday. Asked about the likelihood of a no-deal Brexit, Barclay pointed to the fact that parliament is only due to sit for a relatively short period of time in September and October and that legislation required to pass a deal would be significant. “I think a no deal is underpriced. It is still this government’s intention and both leadership candidates’ intention to seek a deal and I think it is the will of many members of parliament for there to be a deal,” he told a committee of lawmakers. “But the question then will be is there a deal that is palatable to parliament and if not will parliament vote to revoke or will we leave with no deal?” Reporting by Kylie MacLellan, editing by Elizabeth PiperOur Standards:The Thomson Reuters Trust Principles.last_img read more

A Sunken Soviet Sub Is Raising the Radioactivity of the Norwegian Sea

first_img In Photos: WWII-Era Shipwrecks Illegally Plundered in Java Sea A Cold War Soviet nuclear submarine met disaster 30 years ago when it sank in the Norwegian Sea, leading to the deaths of 42 sailors. But instead of lying peacefully at the bottom of the sea, that sub, called the Komsomolets, is leaking radioactive material deep beneath the waves. Several samples collected by an underwater robot from and around the sunken sub’s ventilation duct show that it’s leaking high levels of cesium, a radioactive element, according to the Norwegian Institute of Marine Research (IMR). Some of the cesium levels are 800,000 times higher than normal levels in the Norwegian Sea, according to the institute. However, this radiation does not pose a risk to people or fish, the IMR noted. [Photos: WWII Shipwrecks Found Off NC Coast]Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65931-radioactive-soviet-submarine-leak.html?jwsource=cl已复制直播00:0000:3500:35  The Soviets launched the 400-foot-long (120 meters) Komsomolets, which means “member of the Young Communist League,” in May 1983, according to the U.S. Central Intelligence Agency. While the Komsomolets was on patrol in April 1989, a fire broke out on board, leading to the sub’s eventual demise. As the Komsomolets sank, its two nuclear reactors and at least two torpedoes with plutonium-containing nuclear warheads fell to the bottom of the sea. Since then, the Russians and Norwegians have monitored the wreck, noting its radioactive leaks. “We took water samples from inside this particular duct because the Russians had documented leaks here both in the 1990s and more recently in 2007,” Hilde Elise Heldal, the expedition leader, said in the IMR statement. “So we weren’t surprised to find high levels here.” An analysis showed that one sample had 100 becquerels per liter, compared with the usual 0.001 becquerels per liter normally found in the Norwegian Sea. (A becquerel (Bq) is a unit of radioactivity that represents decay per second.) But Heldal said it was important to put this number into perspective. For instance, following the Chernobyl nuclear disaster, regulations were set for how much cesium would be allowed in foods. “After the Chernobyl accident in 1986, Norwegian authorities set this limit to 600 Bq/kilogram,” she said. So, even though the cesium levels from parts of the submarine “were clearly above what is normal in the oceans,” they still “weren’t alarmingly high,” Heldal said. Moreover, samples taken a few yards from the duct didn’t have any measurable levels of cesium in them. “We didn’t find any measurable levels of radioactive cesium there, unlike in the duct itself,” Justin Gwynn, a researcher at the Norwegian Radiation and Nuclear Safety Authority, said in the statement. Strange cloud But the remotely operated vehicle (ROV), called the Aegir 6000, did catch a strange sight on film: an eerie cloud emanating from the submarine’s duct. After detecting the cloud, the ROV took a sample, which was later found to contain high levels of cesium. Then, the ROV took another sample from a cloud seen rising from a nearby grille. This reading also had high radioactivity levels. Now, the researchers are wondering if this “cloud” is related to the high radioactivity levels in those areas. “It looks very dramatic on video, and it’s definitely interesting, but we don’t really know what we’re seeing and why this phenomenon occurs,” Gwynn said. “It’s something we want to find out more about.” [Photos: WWI-Era German Submarine Wreck Discovered Off Scotland Coast] The researchers plan to study the many samples the ROV collected from the submarine. In the meantime, Heldal stressed that seafood eaters have little to worry about. “What we have found during our survey has very little impact on Norwegian fish and seafood,” she said. “In general, cesium levels in the Norwegian Sea are very low, and as the wreck is so deep, the pollution from Komsomolets is quickly diluted.” Even so, scientists plan to monitor the vessel for years to come, especially since it’s the only known source of radioactive pollution in Norway’s waters. “We need good documentation of pollution levels in seawater, seabed sediments and, of course, fish and seafood,” Heldal said. “So, we’ll continue monitoring both Komsomolets in particular and Norwegian waters in general.” Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoArticles VallyDad Cuts Daughter’s Hair Off For Getting Birthday Highlights, Then Mom Does The UnthinkableArticles VallyUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoCNETMeet the US Navy’s new $13 billion aircraftCNETUndo In Pictures: Japan Earthquake & Tsunami Image Gallery: Stunning Shots of the Titanic Shipwrecklast_img read more

Prasad asks Russia to leverage massive potential of Indias digital economy

first_imgPublished on October 05, 2018 India on Friday invited Russia to leverage the potential of its booming digital economy, with IT Minister Ravi Shankar Prasad saying that collaboration in areas like Artificial Intelligence (AI) and e-health would spur technology momentum of both the economies.Prasad said India is pushing its digital economy to touch USD one trillion mark in coming 3-4 years, leading to opportunities in areas like IT, e-commerce, communications and electronics manufacturing.Terming Indo-Russian relationship as one of “trust, understanding and reciprocity”, Prasad said the two sides had a common world view on a variety of matters and that ties have remained immune from the political changes and other differences.“Indeed, it has acquired a new momentum because of personal chemistry and understanding between Prime Minister Narendra Modi and Russian President Vladimir Putin,” Prasad said addressing India Russia Business Summit organised by industry body CII.Highlighting India’s strength in skilled manpower and innovation and Russia’s technology prowess, Prasad said India too offers a vast potential in emerging areas like AI, e-healthcare and e-education and the booming start-up ecosystem.“When I talk of digital economy, it has already acquired a momentum of its own and is creating an opportunity for industrialists, IT experts, IT professionals and start-ups…India is a big start-up movement with over 5,000 start ups. All this presents a larger narrative….I request all of you to join in India’s digital economy,” Prasad said.He noted that the success of India’s IT industry is backed by skilled talent and low-cost inclusive technology. The mobile phone base in the country stands at 1.21 billion with 450 million smartphones, Prasad said, adding that 1.22 billion Aadhaar cards offered residents a verifiable digital identity.“Indo-Russian relationship offers a great opportunity to work together. Russia has outstanding people, innovators…India is also a land of innovators and human resource including young IT graduates…If we have this kind of collaboration and cooperation, Indo-Russian relationship will acquire a technology momentum of its own,” the minister said. SHARE SHARE EMAIL Ravi Shankar Prasad, Minister of Electronics and Information Technology PTI SHAREcenter_img COMMENT Russia artificial intelligence COMMENTSlast_img read more

General elections in democracy akin to sacred ritual PresidentGeneral elections in democracy

first_img SHARE SHARE EMAIL Saying the general elections in a Democracy were akin to a sacred ritual, President Ram Nath Kovind on Friday urged all citizens to be part of this ritual by participating in the upcoming Lok Sabha polls.“Each vote will encourage another voter, and each vote will strengthen our Democracy,” the President said at a function to celebrate the 9 National Voters Day. The President said every vote counts equally in the formation of the government, adding that large organisations functions under the Election Commission (EC) to ensure that every voter is able to exercise his or her voting right.“The complexity of the task — beginning with the preparation of electoral rolls and concluding with the declaration of election results — is difficult to comprehend for an ordinary person. Yet, through all this, the credibility of our electoral system has continuously strengthened. Our voters have a firm belief in the integrity, diligence, fairness and transparency of the EC and the electoral process,” the President said.The President was also of the opinion that the country’s size and the logistics of holding elections makes it critical to embrace modern technology.Ravi Shankar Prasad, Minister for Law said there was a need to not only trust but also respect the sanctity of the EC.Without naming any political party, the Minister said the electronic voting machines (EVMs) had also decided the victory and defeat of the party that he represented.Inclusive approachSunil Arora, Chief Election Commissioner outlined the various initiatives which the Commission has taken to ensure that all categories of voters are included in the electoral process.“The Commission has taken initiatives for enhancing women’s participation and the turnout of women voters in recent elections has been encouraging,” Arora said adding that the Commission is committed to making the electoral process accessible to all persons with disabilities.Election Commissioner Ashok Lavasa said the gender gap has come down from 16.7 per cent in 1962 elections to 1.5 per cent in 2014 with women’s participation in the electoral process increasing from 46.6 per cent to 65.06 per cent. Published on SHARE January 25, 2019 democracy COMMENTcenter_img Republic Day Urges citizens to take part in the upcoming Lok Sabha polls India Ram Nath Kovind, President of India COMMENTSlast_img read more